慢性病流行病学和共病流行病学,重点关注:
(1)大数据驱动的共病发生发展轨迹识别与预测;
(2)基于多组学的共病病因机制识别。
1. 国家自然科学基金青年项目,基于超大型队列的共病动态发展轨迹及遗传关联研究,,2024-01 至 2026-12,30万,在研,主持
2. 2022年度博士后创新人才支持计划,基因、生活方式与心血管代谢性共病发生发展的因果关联及其交互作用探究,2022-08 至 2025-07,23万元,结题,主持
3. 第72批博士后面上项目资助一等,心血管代谢性共病发生发展不同阶段的遗传易感性和死亡风险的前瞻性队列研究,2022-11 至 2025-07,12万元,结题,主持
4. 四大慢病国家科技重大专项,中国慢性病前瞻性研究示范队列建设研究,2024-08 至 2028-07,5993万元,在研,项目骨干
5. 国家自然科学基金重大项目(子课题),基于中国超大型队列的动脉粥样硬化性心血管疾病基因与环境交互作用研究,2022-01 至 2026-12,330万元,在研,课题骨干
6. 中国工程院学部重大项目(子课题),老年人群的生活质量与健康促进,2022-12 至 2023-12,50万元,结题,课题骨干
1. Han Y, Hu Y, Yu C, Guo Y, Pei P, Yang L, Chen Y, Du H, Sun D, Pang Y, Chen N, Clarke R, Chen J, Chen Z, Li L*, Lv J*, China Kadoorie Biobank Collaborative G. Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study. Eur Heart J 2021;42:3374–3384.
2. Han Y, Hu Y, Yu C, Sun D, Pang Y, Pei P, Yang L, Chen Y, Du H, Liu J, Schmidt D, Avery D, Chen J, Chen Z, Li L*, Lv J*. Duration-dependent impact of cardiometabolic diseases and multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants. Cardiovasc Diabetol 2023;22(1):135.
3. Han Y, Shi H, Yu C, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Guan M, Avery D, Chen J, Chen Z, Li L*, Sun D*, Lv J*. Genetic Risk and Prognosis of the First Incident Stroke Survivors: Findings from China Kadoorie Biobank and UK Biobank. Neurology 2025.
4. Han Y#, Zhu X#, Hu Y, Yu C, Guo Y, Hang D, Pang Y, Pei P, Ma H, Sun D, Yang L, Chen Y, Du H, Yu M, Chen J, Chen Z, Huo D, Jin G, Lv J*, Hu Z, Shen H, Li L. Electronic Health Record–Based Absolute Risk Prediction Model for Esophageal Cancer in the Chinese Population: Model Development and External Validation. JMIR Public Health Surveill 2023;9:e43725.
5. Han Y, Lv J, Yu C, Guo Y, Bian Z, Hu Y, Yang L, Chen Y, Du H, Zhao F, Wen W, Shu XO, Xiang Y, Gao YT, Zheng W, Guo H, Liang P, Chen J, Chen Z, Huo D*, Li L*, China Kadoorie Biobank Collaborative G. Development and external validation of a breast cancer absolute risk prediction model in Chinese population. Breast cancer research 2021;23:62.
6. Zhu M#, Han Y#, Mou Y#, Meng X#, Ji C, Zhu X, Yu C, Sun D, Yang L, Sun Q, Chen Y, Du H, Dai J, Chen Z, Hu Z, Lv J, Jin G, Ma H, Kan H*, Li L*, Shen H*. Effect of Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers. Am J Respir Crit Care Med 2025;211(4):600-609.
7. Xu H-M#, Han Y#, Liu Z-C, Yin Z-Y, Wang M-Y, Yu C, Ma J-L, Sun D, Liu W-D, Zhang Y, Zhou T, Zhang J-Y, Pei P, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Chen Z, You W-C, Li L, Pan K-F*, Lv J*, Li W-Q*. Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer. JAMA Netw Open 2024;7(5):e2413708.
8. Zhu M#, Zhu X#, Han Y#, Ma Z, Ji C, Wang T, Yan C, Song C, Yu C, Sun D, Jiang Y, Chen J, Yang L, Chen Y, Du H, Walters R, Millwood IY, Dai J, Ma H, Zhang Z, Chen Z, Hu Z, Lv J, Jin G, Li L, Shen H, Group on behalf of the CKBC. Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank. PLOS Medicine 2025;22(2):e1004534.
9. Han Y, He Y, Lyu J, Yu C, Bian M, Lee L*. Aging in China: perspectives on public health. Global Health Journal 2020;4:11–17.
10. 韩雨廷, 吕筠, 余灿清, 李立明*. 数字公共卫生的进展与应用. 中华流行病学杂志 2022;43:791–797.